Epigenetics of endometriosis

NEW RESEARCH HORIZON Review Epigenetics of endometriosis

Endometriosis is a common gynecologic disorder with an enigmatic etiopathogenesis. Although it has been proposed that endometriosis is a hormonal disease, an autoimmune disease, a genetic disease, and a disease caused by exposure to environmental toxins, our understanding of its etiopathogenesis is still inadequate, as reflected by recent apparent setbacks in clinical trials on endometriosis. I...

Epigenetics: an emerging research field of infertility associated with endometriosis

Endometriosis is a common gynecologic disease, which is characterized by the presence of uterine endometrial tissue outside the uterine cavity. It is associated with several complications, including pelvic pain, dysmenorrheal and infertility. Endometriosis has drawn wide attention due to its close involvement of infertility in various ways. There are several factors hindering gynecological doct...

The Prospects of Epigenetics in Neuroscience

Aberrant DNA methylation status of endometriosis: epigenetics as the pathogenesis, biomarker and therapeutic target.

Endometriosis, a common, benign, estrogen-dependent disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue that is found primarily in the peritoneum, ovaries and rectovaginal septum. Recently, endometriosis has been alternatively described as an immune disease, a genetic disease and a disease caused by exposure to environmental factors...

Nuclear Architecture and Epigenetics of Lineage Choice

Differentiation is an epigenetic process which is installed by changes of transcriptional programs over successive cellular divisions. A number of studies have reported the effects of biochemical modifications of chromatin (DNA and chromatin proteins) on the regulation of transcription. Although, these studies are able to explain how transcription of a given gene is regulated (toward activation...